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GATA-3 is involved in the development of serotonergic neurons in the caudal raphe nuclei.

The GATA-3 transcription factor shows a specific and restricted expression pattern in the developing and adult mouse brain. In the present study we investigated the role of GATA-3 in the caudal raphe system, which is known to operate as a modulator of motor activity. We demonstrate that virtually all neurons in the caudal raphe nuclei that express GATA-3 also produce serotonin. Absence of GATA-3, as analyzed in chimeric -/- mice, affects the cytoarchitecture of serotonergic neurons in the caudal raphe nuclei. As a result the chimeras show a serious defect in their locomotor performance on a rotating rod. In sum, we conclude that GATA-3 plays a major role in the development of the serotonergic neurons of the caudal raphe nuclei, and that it is crucial for their role in locomotion.

Pubmed ID: 10366650

Authors

  • van Doorninck JH
  • van Der Wees J
  • Karis A
  • Goedknegt E
  • Engel JD
  • Coesmans M
  • Rutteman M
  • Grosveld F
  • De Zeeuw CI

Journal

The Journal of neuroscience : the official journal of the Society for Neuroscience

Publication Data

June 15, 1999

Associated Grants

None

Mesh Terms

  • Animals
  • Brain Stem
  • Chimera
  • DNA-Binding Proteins
  • GATA3 Transcription Factor
  • Immunohistochemistry
  • Lac Operon
  • Mice
  • Mice, Mutant Strains
  • Motor Activity
  • Neurons
  • Raphe Nuclei
  • Serotonin
  • Trans-Activators