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The DNA mismatch repair genes Msh3 and Msh6 cooperate in intestinal tumor suppression.

Repair of mismatches in DNA in mammalian cells is mediated by a complex of proteins that are members of two highly conserved families of genes referred to as MutS and MutL homologues. Germline mutations in several members of these families, MSH2, MSH6, MLH1, and PMS2, but not MSH3, are responsible for hereditary non-polyposis colorectal cancer. To examine the role of MSH3, we generated a mouse with a null mutation in this gene. Cells from Msh3-/- mice are defective in repair of insertion/ deletion mismatches but can repair base-base mismatches. Msh3-/- mice develop tumors at a late age. When the Msh3-/- and Msh6-/- mutations are combined, the tumor predisposition phenotype is indistinguishable from Msh2-/- or Mlh1-/- mice. These results suggest that MSH3 cooperates with MSH6 in tumor suppression.

Pubmed ID: 10706084

Authors

  • Edelmann W
  • Umar A
  • Yang K
  • Heyer J
  • Kucherlapati M
  • Lia M
  • Kneitz B
  • Avdievich E
  • Fan K
  • Wong E
  • Crouse G
  • Kunkel T
  • Lipkin M
  • Kolodner RD
  • Kucherlapati R

Journal

Cancer research

Publication Data

February 15, 2000

Associated Grants

  • Agency: NCI NIH HHS, Id: CA67944
  • Agency: NCI NIH HHS, Id: CA76329
  • Agency: NCI NIH HHS, Id: CA84301

Mesh Terms

  • Animals
  • Base Pair Mismatch
  • DNA Repair
  • DNA-Binding Proteins
  • Female
  • Fungal Proteins
  • Humans
  • Intestinal Neoplasms
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Multidrug Resistance-Associated Proteins
  • Mutation
  • Saccharomyces cerevisiae Proteins