Nat. Neurosci. 2000 Aug
Gotter AL, Manganaro T, Weaver DR, Kolakowski LF, Possidente B, Sriram S, MacLaughlin DT, Reppert SM
The timeless (tim) gene is essential for circadian clock function in Drosophila melanogaster. A putative mouse homolog, mTimeless (mTim), has been difficult to place in the circadian clock of mammals. Here we show that mTim is essential for embryonic development, but does not have substantiated circadian function.
Animals, CLOCK Proteins, Cell Cycle Proteins, Chimera, Circadian Rhythm, Genes, Reporter, Heterozygote, Humans, Intracellular Signaling Peptides and Proteins, Luciferases, Mice, Mice, Inbred Strains, Mice, Knockout, Molecular Sequence Data, Mutagenesis, Site-Directed, Phylogeny, Recombinant Proteins, Spodoptera, Suprachiasmatic Nucleus, Trans-Activators, Transcription Factors, Transcription, Genetic, Transfection