Conserved function for embryonic nodal cilia.
Journal:
Nature 2002 JulAuthors:
Essner JJ, Vogan KJ, Wagner MK, Tabin CJ, Yost HJ, Brueckner M
Abstract
How left right handedness originates in the body plan of the developing vertebrate embryo is a subject of considerable debate. In mice, a left right bias is thought to arise from a directional extracellular flow (nodal flow) that is generated by dynein-dependent rotation of monocilia on the ventral surface of the embryonic node. Here we show that the existence of node monocilia and the expression of a dynein gene that is implicated in ciliary function are conserved across a wide range of vertebr
...[more]ate classes, indicating that a similar ciliary mechanism may underlie the establishment of handedness in all vertebrates.[less]
Mesh Headings:
Animals, Axonemal Dyneins, Body Patterning, Chick Embryo, Cilia, Conserved Sequence, Dyneins, Embryo, Mammalian, Embryo, Nonmammalian, Gastrula, Gene Expression Profiling, Gene Expression Regulation, Developmental, Mice, Organizers, Embryonic, Signal Transduction, Vertebrates, Xenopus, Zebrafish, Zebrafish Proteins