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Escrt-III: an endosome-associated heterooligomeric protein complex required for mvb sorting.

The sorting of transmembrane proteins (e.g., cell surface receptors) into the multivesicular body (MVB) pathway to the lysosomal/vacuolar lumen requires the function of the ESCRT protein complexes. The soluble coiled-coil-containing proteins Vps2, Vps20, Vps24, and Snf7 are recruited from the cytoplasm to endosomal membranes where they oligomerize into a protein complex, ESCRT-III. ESCRT-III contains two functionally distinct subcomplexes. The Vps20-Snf7 subcomplex binds to the endosomal membrane, in part via the myristoyl group of Vps20. The Vps2-Vps24 subcomplex binds to the Vps20-Snf7 complex and thereby serves to recruit additional cofactors to this site of protein sorting. We provide evidence for a role for ESCRT-III in sorting and/or concentration of MVB cargoes.

Pubmed ID: 12194857

Authors

  • Babst M
  • Katzmann DJ
  • Estepa-Sabal EJ
  • Meerloo T
  • Emr SD

Journal

Developmental cell

Publication Data

August 26, 2002

Associated Grants

  • Agency: NCI NIH HHS, Id: CA58689

Mesh Terms

  • Animals
  • Carrier Proteins
  • Cell Compartmentation
  • Cell Membrane
  • Endosomal Sorting Complexes Required for Transport
  • Endosomes
  • Escherichia coli
  • Eukaryotic Cells
  • Fungal Proteins
  • Lysosomes
  • Macromolecular Substances
  • Membrane Proteins
  • Microscopy, Electron
  • Mutation
  • Nuclear Proteins
  • Peptide Hydrolases
  • Protein Transport
  • Saccharomyces cerevisiae
  • Saccharomyces cerevisiae Proteins
  • Transport Vesicles
  • trans-Golgi Network