IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway.
Journal:
Nat. Immunol. 2003 MayAuthors:
Fitzgerald KA, McWhirter SM, Faia KL, Rowe DC, Latz E, Golenbock DT, Coyle AJ, Liao SM, Maniatis T
Abstract
The transcription factors interferon regulatory factor 3 (IRF3) and NF-kappaB are required for the expression of many genes involved in the innate immune response. Viral infection, or the binding of double-stranded RNA to Toll-like receptor 3, results in the coordinate activation of IRF3 and NF-kappaB. Activation of IRF3 requires signal-dependent phosphorylation, but little is known about the signaling pathway or kinases involved. Here we report that the noncanonical IkappaB kinase homologs, Ika
...[more]ppaB kinase-epsilon (IKKepsilon) and TANK-binding kinase-1 (TBK1), which were previously implicated in NF-kappaB activation, are also essential components of the IRF3 signaling pathway. Thus, IKKepsilon and TBK1 have a pivotal role in coordinating the activation of IRF3 and NF-kappaB in the innate immune response.[less]
Mesh Headings:
Adaptor Proteins, Vesicular Transport, Chemokine CCL5, DNA-Binding Proteins, Drosophila Proteins, Gene Expression Regulation, Humans, I-kappa B Kinase, Immunity, Innate, Interferon Regulatory Factor-3, Interferon-beta, Membrane Glycoproteins, NF-kappa B, Protein-Serine-Threonine Kinases, RNA Interference, Receptors, Cell Surface, Signal Transduction, Toll-Like Receptor 3, Toll-Like Receptors, Transcription Factors, Virus Diseases