PEST domain-enriched tyrosine phosphatase (PEP) regulation of effector/memory T cells.
Journal:
Science 2004 JanAuthors:
Hasegawa K, Martin F, Huang G, Tumas D, Diehl L, Chan AC
Abstract
Protein tyrosine kinases and phosphatases cooperate to regulate normal immune cell function. We examined the role of PEST domain-enriched tyrosine phosphatase (PEP) in regulating T cell antigen-receptor function during thymocyte development and peripheral T cell differentiation. Although normal naïve T cell functions were retained in pep-deficient mice, effector/memory T cells demonstrated enhanced activation of Lck. In turn, this resulted in increased expansion and function of the effector/mem
...[more]ory T cell pool, which was also associated with spontaneous development of germinal centers and elevated serum antibody levels. These results revealed a central role for PEP in negatively regulating specific aspects of T cell development and function.[less]
Mesh Headings:
Animals, Autoimmunity, B-Lymphocytes, CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes, Cell Cycle, Gene Targeting, Germinal Center, Hydrogen-Ion Concentration, Immunoglobulins, Immunologic Memory, Lymphocyte Activation, Lymphocyte Count, Lymphocyte Specific Protein Tyrosine Kinase p56(lck), Mice, Mice, Inbred BALB C, Mice, Transgenic, Phosphorylation, Protein Tyrosine Phosphatase, Non-Receptor Type 12, Protein Tyrosine Phosphatases, Receptors, Antigen, T-Cell, Signal Transduction, T-Lymphocyte Subsets, T-Lymphocytes