X

Forgot your Password

If you have forgotten your password, please enter your account email below and we will reset your password and email you the new password.

X

Login to SciCrunch

X

Register an Account

Delete Saved Search

Are you sure you want to delete this saved search?

NO

NIF LinkOut Portal

FILTERS

Neural correlates of a reversal learning task with an affectively neutral baseline: an event-related fMRI study.

Authors:
Remijnse PL, Nielen MM, Uylings HB, Veltman DJ
Affiliation:
Journal:
NeuroImage

Abstract

Reversal learning may conceptually be dissected into acquiring stimulus-reinforcement associations and subsequently altering behavior by switching to new associations as stimulus-reinforcement contingencies reverse (i.e., affective switching). Previous imaging studies have found regions of the ventrolateral and orbitofrontal cortex (OFC) to be involved in both subprocesses. However, these studies did not contain an affectively neutral baseline, which precluded adequate assessment of main effects of reward, punishment, and affective switching. We aimed to determine the neural substrate of these main effects, and of common and dissociable regions for reward and punishment. Furthermore, we aimed to discriminate between stimulus-punishment association and affective switching, i.e., to assess affective switching proper. To this end, we implemented a reversal learning task with an affectively neutral baseline condition that matched the experimental task in visual complexity and motor demands. Interestingly, we found dorsolateral prefrontal cortex (DLPFC) and anterior PFC to be engaged in affective switching, a finding that has not been reported before to our knowledge. Enhanced responses in these areas may represent their involvement in cognitive set shifting per se unrelated to the affective context in a reversal learning design. In addition, OFC, insular and medial prefrontal cortex regions were involved in affective switching. Left medial and lateral OFC were shown to be common areas for feedback processing, whereas left ventral striatum and left lateral OFC were specifically activated by reward and punishment, respectively. These results extend our understanding of the neural substrate of reversal learning in humans.

NeuroSynth Links

  1. Welcome

    Welcome to NIF. Explore available research resources: data, tools and materials, from across the web

  2. Community Resources

    Search for resources specially selected for NIF community

  3. More Resources

    Search across hundreds of additional biomedical databases

  4. Literature

    Search Pub Med abstracts and full text from PubMed Central

  5. Insert your Query

    Enter your search terms here and hit return. Search results for the selected tab will be returned.

  6. Join the Community

    Click here to login or register and join this community.

  7. Categories

    Narrow your search by selecting a category. For additional help in searching, view our tutorials.

  8. Query Info

    Displays the total number of search results. Provides additional information on search terms, e.g., automated query expansions, and any included categories or facets. Expansions, filters and facets can be removed by clicking on the X. Clicking on the + restores them.

  9. Search Results

    Displays individual records and a brief description. Click on the icons below each record to explore additional display options.

X