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DNA-dependent conversion of Oct-1 and Oct-2 into transcriptional repressors by Groucho/TLE.

Authors:
Malin S, Linderson Y, Almqvist J, Ernberg I, Tallone T, Pettersson S
Affiliation:
Journal:
Nucleic acids research

Abstract

POU domain proteins contain a bipartite DNA-binding element that can confer allosteric control of coactivator recruitment. Dimerization of Oct-1 and Oct-2 on palindromic response elements results in the conformational dependent inclusion or exclusion of the transcriptional coactivator OBF-1. In this paper, we demonstrate that Oct-1 and Oct-2 can function as transcriptional repressors by recruiting and physically interacting with members of the Grg/TLE family of corepressors. In accordance with a model of DNA induced cofactor assembly, and analogous to the recruitment of the OBF-1 coactivator, the different Grg/TLE members can discriminate between both Oct-1 and Oct-2, and the monomeric or dimeric nature of the POU/DNA complex.

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