Lethal influenza infection in the absence of the natural killer cell receptor gene Ncr1.
Journal:
Nat. Immunol. 2006 MayAuthors:
Gazit R, Gruda R, Elboim M, Arnon TI, Katz G, Achdout H, Hanna J, Qimron U, Landau G, Greenbaum E, Zakay-Rones Z, Porgador A, Mandelboim O
Abstract
The elimination of viruses and tumors by natural killer cells is mediated by specific natural killer cell receptors. To study the in vivo function of a principal activating natural killer cell receptor, NCR1 (NKp46 in humans), we replaced the gene encoding this receptor (Ncr1) with a green fluorescent protein reporter cassette. There was enhanced spread of certain tumors in 129/Sv but not C57BL/6 Ncr1(gfp/gfp) mice, and influenza virus infection was lethal in both 129/Sv and C57BL/6 Ncr1(gfp/gfp
...[more]) mice. We noted accumulation of natural killer cells at the site of influenza infection by tracking the green fluorescent protein. Our results demonstrate a critical function for Ncr1 in the in vivo eradication of influenza virus.[less]
Mesh Headings:
Animals, Cell Line, Green Fluorescent Proteins, Humans, Immunity, Innate, Influenza A virus, Killer Cells, Natural, Mice, Mice, Knockout, Natural Cytotoxicity Triggering Receptor 1, Orthomyxoviridae Infections, Receptors, Immunologic, Species Specificity, Survival Rate