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Hippocampal and amygdalar volumes in dissociative identity disorder.

OBJECTIVE: Smaller hippocampal volume has been reported in several stress-related psychiatric disorders, including posttraumatic stress disorder (PTSD), borderline personality disorder with early abuse, and depression with early abuse. Patients with borderline personality disorder and early abuse have also been found to have smaller amygdalar volume. The authors examined hippocampal and amygdalar volumes in patients with dissociative identity disorder, a disorder that has been associated with a history of severe childhood trauma. METHOD: The authors used magnetic resonance imaging to measure the volumes of the hippocampus and amygdala in 15 female patients with dissociative identity disorder and 23 female subjects without dissociative identity disorder or any other psychiatric disorder. The volumetric measurements for the two groups were compared. RESULTS: Hippocampal volume was 19.2% smaller and amygdalar volume was 31.6% smaller in the patients with dissociative identity disorder, compared to the healthy subjects. The ratio of hippocampal volume to amygdalar volume was significantly different between groups. CONCLUSIONS: The findings are consistent with the presence of smaller hippocampal and amygdalar volumes in patients with dissociative identity disorder, compared with healthy subjects.

Pubmed ID: 16585437

Authors

  • Vermetten E
  • Schmahl C
  • Lindner S
  • Loewenstein RJ
  • Bremner JD

Journal

The American journal of psychiatry

Publication Data

April 4, 2006

Associated Grants

  • Agency: NIMH NIH HHS, Id: K24 MH076955
  • Agency: NIMH NIH HHS, Id: K24 MH076955-05
  • Agency: NIMH NIH HHS, Id: MH-56120
  • Agency: NIMH NIH HHS, Id: R01 MH056120
  • Agency: NIMH NIH HHS, Id: R01 MH056120-12
  • Agency: NIMH NIH HHS, Id: R21 MH080208
  • Agency: NIMH NIH HHS, Id: R21 MH080208-02
  • Agency: NCRR NIH HHS, Id: S10 RR016917
  • Agency: NCRR NIH HHS, Id: S10 RR016917-01
  • Agency: NIMH NIH HHS, Id: T32 MH067547
  • Agency: NIMH NIH HHS, Id: T32 MH067547-05

Mesh Terms

  • Adult
  • Amygdala
  • Atrophy
  • Child
  • Child Abuse
  • Comorbidity
  • Depressive Disorder, Major
  • Female
  • Functional Laterality
  • Hippocampus
  • Humans
  • Magnetic Resonance Imaging
  • Multiple Personality Disorder
  • Psychiatric Status Rating Scales
  • Sex Factors
  • Stress Disorders, Post-Traumatic