Cortical 5-HT2A receptor signaling modulates anxiety-like behaviors in mice.
Journal:
Science 2006 JulAuthors:
Weisstaub NV, Zhou M, Lira A, Lambe E, González-Maeso J, Hornung JP, Sibille E, Underwood M, Itohara S, Dauer WT, Ansorge MS, Morelli E, Mann JJ, Toth M, Aghajanian G, Sealfon SC, Hen R, Gingrich JA
Abstract
Serotonin [5-hydroxytryptamine (5-HT)] neurotransmission in the central nervous system modulates depression and anxiety-related behaviors in humans and rodents, but the responsible downstream receptors remain poorly understood. We demonstrate that global disruption of 5-HT2A receptor (5HT2AR) signaling in mice reduces inhibition in conflict anxiety paradigms without affecting fear-conditioned and depression-related behaviors. Selective restoration of 5HT2AR signaling to the cortex normalized con
...[more]flict anxiety behaviors. These findings indicate a specific role for cortical 5HT2AR function in the modulation of conflict anxiety, consistent with models of cortical, "top-down" influences on risk assessment.[less]
Mesh Headings:
Animals, Anxiety, Cerebral Cortex, Conditioning (Psychology), Conflict (Psychology), Depression, Exploratory Behavior, Fear, Limbic System, Mice, Mice, Knockout, Patch-Clamp Techniques, Periaqueductal Gray, Prosencephalon, Receptor, Serotonin, 5-HT2A, Receptor, Serotonin, 5-HT2C, Receptors, Neurotransmitter, Risk-Taking, Serotonin, Signal Transduction, Synaptic Transmission