Regulation of the germinal center response by microRNA-155.
Journal:
Science 2007 AprAuthors:
Thai TH, Calado DP, Casola S, Ansel KM, Xiao C, Xue Y, Murphy A, Frendewey D, Valenzuela D, Kutok JL, Schmidt-Supprian M, Rajewsky N, Yancopoulos G, Rao A, Rajewsky K
Abstract
MicroRNAs are small RNA species involved in biological control at multiple levels. Using genetic deletion and transgenic approaches, we show that the evolutionarily conserved microRNA-155 (miR-155) has an important role in the mammalian immune system, specifically in regulating T helper cell differentiation and the germinal center reaction to produce an optimal T cell-dependent antibody response. miR-155 exerts this control, at least in part, by regulating cytokine production. These results also
...[more] suggest that individual microRNAs can exert critical control over mammalian differentiation processes in vivo.[less]
Mesh Headings:
Animals, B-Lymphocytes, Cell Differentiation, Cells, Cultured, Cytokines, Germinal Center, Immunoglobulin G, Lymphocyte Activation, Lymphotoxin-alpha, Lymphotoxin-beta, Mice, Mice, Knockout, Mice, Transgenic, MicroRNAs, Nitrophenols, Peyer's Patches, Phenylacetates, Somatic Hypermutation, Immunoglobulin, Spleen, T-Lymphocytes, Th1 Cells, Th2 Cells, Tumor Necrosis Factor-alpha