Regulation of B versus T lymphoid lineage fate decision by the proto-oncogene LRF.
Journal:
Science 2007 MayAuthors:
Maeda T, Merghoub T, Hobbs RM, Dong L, Maeda M, Zakrzewski J, van den Brink MR, Zelent A, Shigematsu H, Akashi K, Teruya-Feldstein J, Cattoretti G, Pandolfi PP
Abstract
Hematopoietic stem cells in the bone marrow give rise to lymphoid progenitors, which subsequently differentiate into B and T lymphocytes. Here we show that the proto-oncogene LRF plays an essential role in the B versus T lymphoid cell-fate decision. We demonstrate that LRF is key for instructing early lymphoid progenitors in mice to develop into B lineage cells by repressing T cell-instructive signals produced by the cell-fate signal protein, Notch. We propose a new model for lymphoid lineage co
...[more]mmitment, in which LRF acts as a master regulator of the cell's determination of B versus T lineage.[less]
Mesh Headings:
Animals, B-Lymphocytes, Bone Marrow Cells, Cell Lineage, Cells, Cultured, DNA-Binding Proteins, Gene Deletion, Hematopoietic Stem Cells, Lymphopoiesis, Mice, Mice, Inbred C57BL, Mice, Knockout, Models, Biological, Proto-Oncogenes, Receptors, Notch, Signal Transduction, T-Lymphocytes, Thymus Gland, Transcription Factors