Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database.
In an effort to pinpoint potential genetic risk factors for schizophrenia, research groups worldwide have published over 1,000 genetic association studies with largely inconsistent results. To facilitate the interpretation of these findings, we have created a regularly updated online database of all published genetic association studies for schizophrenia ('SzGene'). For all polymorphisms having genotype data available in at least four independent case-control samples, we systematically carried out random-effects meta-analyses using allelic contrasts. Across 118 meta-analyses, a total of 24 genetic variants in 16 different genes (APOE, COMT, DAO, DRD1, DRD2, DRD4, DTNBP1, GABRB2, GRIN2B, HP, IL1B, MTHFR, PLXNA2, SLC6A4, TP53 and TPH1) showed nominally significant effects with average summary odds ratios of approximately 1.23. Seven of these variants had not been previously meta-analyzed. According to recently proposed criteria for the assessment of cumulative evidence in genetic association studies, four of the significant results can be characterized as showing 'strong' epidemiological credibility. Our project represents the first comprehensive online resource for systematically synthesized and graded evidence of genetic association studies in schizophrenia. As such, it could serve as a model for field synopses of genetic associations in other common and genetically complex disorders.
Pubmed ID: 18583979
- Allen NC
- Bagade S
- McQueen MB
- Ioannidis JP
- Kavvoura FK
- Khoury MJ
- Tanzi RE
- Bertram L
July 27, 2008
- Agency: NICHD NIH HHS, Id: R01 HD060726
- Case-Control Studies
- Databases, Genetic
- Gene Frequency
- Genetic Heterogeneity
- Genetic Linkage
- Genetic Predisposition to Disease
- Polymorphism, Single Nucleotide
- Lipoprotein glomerulopathy is related to genes APOE, AD2, LPG, LDLCQ5.
- Sea-blue histiocyte disease is related to genes APOE, AD2, LPG, LDLCQ5 which are autosomal recessive according to the OMIM database.
- Neural tube defects, susceptibility to is related to gene MTHFR which is autosomal recessive according to the OMIM database.
- Homocystinuria due to MTHFR deficiency is related to gene MTHFR which is autosomal recessive according to the OMIM database.
- Alzheimer disease-2 is related to genes APOE, AD2, LPG, LDLCQ5 which are autosomal dominant according to the OMIM database.
- Schizophrenia, susceptibility to is related to gene MTHFR which is autosomal dominant according to the OMIM database.
- Hermansky-Pudlak syndrome 7 is related to genes DTNBP1, HPS7.