Nat. Struct. Mol. Biol. 2008 Aug
Zhou Z, Feng H, Hansen DF, Kato H, Luk E, Freedberg DI, Kay LE, Wu C, Bai Y
The NMR structure of budding yeast chaperone Chz1 complexed with histones H2A.Z-H2B has been determined. Chz1 forms a long irregular chain capped by two short alpha-helices, and uses both positively and negatively charged residues to stabilize the histone dimer. A molecular model that docks Chz1 onto the nucleosome has implications for its potential functions.
Arginine, Carbon, Dimerization, Histone Chaperones, Histones, Lysine, Magnetic Resonance Spectroscopy, Molecular Chaperones, Molecular Conformation, Nitrogen, Nucleosomes, Protein Conformation, Protein Structure, Secondary, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins, Static Electricity