Stress and addiction: glucocorticoid receptor in dopaminoceptive neurons facilitates cocaine seeking.
Journal:
Nat. Neurosci. 2009 MarAuthors:
Ambroggi F, Turiault M, Milet A, Deroche-Gamonet V, Parnaudeau S, Balado E, Barik J, van der Veen R, Maroteaux G, Lemberger T, Schütz G, Lazar M, Marinelli M, Piazza PV, Tronche F
Abstract
The glucocorticoid receptor is a ubiquitous transcription factor mediating adaptation to environmental challenges and stress. Selective Nr3c1 (the glucocorticoid receptor gene) ablation in mouse dopaminoceptive neurons expressing dopamine receptor 1a, but not in dopamine-releasing neurons, markedly decreased the motivation of mice to self-administer cocaine, dopamine cell firing and the control exerted by dopaminoceptive neurons on dopamine cell firing activity. In contrast, anxiety was unaffect
...[more]ed, indicating that glucocorticoid receptors modify a number of behavioral disorders through different neuronal populations.[less]
Mesh Headings:
Animals, Behavior, Addictive, Cocaine, Cocaine-Related Disorders, Dopamine, Mice, Mice, Transgenic, Neurons, Receptors, Dopamine D1, Receptors, Glucocorticoid, Self Administration, Stress, Psychological