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Thymic OX40 expression discriminates cells undergoing strong responses to selection ligands.

OX40 is a member of the TNF receptor family expressed on activated and regulatory T (Treg) cells. Using an Ox40-cre allele for lineage marking, we found that a subpopulation of naive T cells had also previously expressed OX40 in the thymus. Ox40-cre was induced in a small fraction of thymocytes that were OX40(+), some of which were CD25(high) Treg cell precursors. Thymic OX40 expression distinguished cells experiencing a strong signaling response to positive selection. Naive T cells that had previously expressed OX40 demonstrated a partially activated phenotype that was distinct from that of most naive T cells. The results are consistent with the selection of Treg cells and a minor subpopulation of naive T cells being dependent on strong signaling responses to thymic self ligands.

Pubmed ID: 19342632

Authors

  • Klinger M
  • Kim JK
  • Chmura SA
  • Barczak A
  • Erle DJ
  • Killeen N

Journal

Journal of immunology (Baltimore, Md. : 1950)

Publication Data

April 15, 2009

Associated Grants

  • Agency: NIAID NIH HHS, Id: AI39506
  • Agency: NIAID NIH HHS, Id: R01 AI039506
  • Agency: NIAID NIH HHS, Id: R01 AI039506-09

Mesh Terms

  • Animals
  • Antigens, CD44
  • Gene Expression Regulation
  • Genes, Reporter
  • Integrases
  • Ligands
  • Lymph Nodes
  • Lymphocyte Activation
  • Membrane Glycoproteins
  • Mice
  • Mice, Transgenic
  • Receptors, Antigen, T-Cell
  • Signal Transduction
  • Thymus Gland
  • Tumor Necrosis Factors