• Register
X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

X

Leaving Community

Are you sure you want to leave this community? Leaving the community will revoke any permissions you have been granted in this community.

No
Yes

Hippocampus and amygdala volumes in patients with borderline personality disorder with or without posttraumatic stress disorder.

BACKGROUND: Several studies have investigated volumetric brain changes in patients with posttraumatic stress disorder (PTSD) and borderline personality disorder (BPD). Both groups exhibit volume reductions of the hippocampus and amygdala. Our aim was to investigate the influence of comorbid PTSD on hippocampus and amygdala volumes in patients with BPD. METHODS: We compared 2 groups of unmedicated female patients with BPD (10 with and 15 without comorbid PTSD) and 25 healthy female controls. We used T(1)- and T(2)-weighted magnetic resonance images for manual tracing and 3-dimensional reconstruction of the hippocampus and amygdala. RESULTS: Hippocampus volumes of patients with BPD and PTSD were smaller than those of healthy controls. However, there was no significant difference between patients with BPD but without PTSD and controls. Impulsiveness was positively correlated with hippocampus volumes in patients with BPD. LIMITATIONS: Our study did not allow for disentangling the effects of PTSD and traumatization. Another limitation was the relatively small sample size. CONCLUSION: Our findings highlight the importance of classifying subgroups of patients with BPD. Comorbid PTSD may be related to volumetric alterations in brain regions that are of central importance to our understanding of borderline psychopathology.

Pubmed ID: 19568480

Authors

  • Schmahl C
  • Berne K
  • Krause A
  • Kleindienst N
  • Valerius G
  • Vermetten E
  • Bohus M

Journal

Journal of psychiatry & neuroscience : JPN

Publication Data

July 1, 2009

Associated Grants

None

Mesh Terms

  • Adult
  • Amygdala
  • Borderline Personality Disorder
  • Case-Control Studies
  • Female
  • Hippocampus
  • Humans
  • Magnetic Resonance Imaging
  • Psychiatric Status Rating Scales
  • Severity of Illness Index
  • Stress Disorders, Post-Traumatic