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Conducting clinical research with prescription opioid dependence: defining the population.

Most treatment studies of opioid-dependent populations have focused predominantly on heroin users, despite a recent increase in those dependent upon prescription opioids. A key methodological challenge involved in studying the latter group involves defining the population. Specifically, researchers must decide whether to include (1) concurrent heroin users and (2) individuals with pain. The multi-site Prescription Opioid Addiction Treatment Study is examining treatments for this population. This paper describes various inclusion criteria considered by the study team related to heroin use and pain. The goal was to recruit a distinct but generalizable population of individuals dependent upon prescription opioids. (Am J Addict 2010;00:1-6).

Pubmed ID: 20163386

Authors

  • Weiss RD
  • Potter JS
  • Copersino ML
  • Prather K
  • Jacobs P
  • Provost S
  • Chim D
  • Selzer J
  • Ling W

Journal

The American journal on addictions / American Academy of Psychiatrists in Alcoholism and Addictions

Publication Data

February 18, 2010

Associated Grants

  • Agency: NIDA NIH HHS, Id: K23 DA022297
  • Agency: NIDA NIH HHS, Id: K24 DA022288
  • Agency: NIDA NIH HHS, Id: K24 DA022288
  • Agency: NIDA NIH HHS, Id: K24 DA022288-03
  • Agency: NIDA NIH HHS, Id: T32 DA07272
  • Agency: NIDA NIH HHS, Id: U10 DA013045
  • Agency: NIDA NIH HHS, Id: U10 DA013045
  • Agency: NIDA NIH HHS, Id: U10 DA015831
  • Agency: NIDA NIH HHS, Id: U10 DA015831-08
  • Agency: NIDA NIH HHS, Id: U10 DA13035
  • Agency: NIDA NIH HHS, Id: U10 DA15831

Mesh Terms

  • Analgesics, Opioid
  • Clinical Trials as Topic
  • Humans
  • Opioid-Related Disorders
  • Pain
  • Patient Selection
  • Prescription Drugs