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Host determinants of HIV-1 control in African Americans.

We performed a whole-genome association study of human immunodeficiency virus type 1 (HIV-1) set point among a cohort of African Americans (n = 515), and an intronic single-nucleotide polymorphism (SNP) in the HLA-B gene showed one of the strongest associations. We use a subset of patients to demonstrate that this SNP reflects the effect of the HLA-B*5703 allele, which shows a genome-wide statistically significant association with viral load set point (P = 5.6 x 10(-10)). These analyses therefore confirm a member of the HLA-B*57 group of alleles as the most important common variant that influences viral load variation in African Americans, which is consistent with what has been observed for individuals of European ancestry, among whom the most important common variant is HLA-B*5701.

Pubmed ID: 20205591

Authors

  • Pelak K
  • Goldstein DB
  • Walley NM
  • Fellay J
  • Ge D
  • Shianna KV
  • Gumbs C
  • Gao X
  • Maia JM
  • Cronin KD
  • Hussain SK
  • Carrington M
  • Michael NL
  • Weintrob AC
  • Infectious Disease Clinical Research Program HIV Working Group
  • National Institute of Allergy and Infectious Diseases Center for HIV/AIDS Vaccine Immunology (CHAVI)

Journal

The Journal of infectious diseases

Publication Data

April 15, 2010

Associated Grants

  • Agency: NIGMS NIH HHS, Id: 5 T32 GM007754-29
  • Agency: NCRR NIH HHS, Id: 5-M01-RR-00052
  • Agency: NIAID NIH HHS, Id: AI067854
  • Agency: PHS HHS, Id: HHSN261200800001E
  • Agency: PHS HHS, Id: HU0001-05-2-0011
  • Agency: NCI NIH HHS, Id: K07 CA140360
  • Agency: NIAID NIH HHS, Id: U01-AI-35039
  • Agency: NIAID NIH HHS, Id: U01-AI-35040
  • Agency: NIAID NIH HHS, Id: U01-AI-35041
  • Agency: NIAID NIH HHS, Id: U01-AI-35042
  • Agency: NIAID NIH HHS, Id: U01-AI-35043
  • Agency: NIAID NIH HHS, Id: U01-AI-37613
  • Agency: NIAID NIH HHS, Id: U01-AI-37984
  • Agency: NIAID NIH HHS, Id: Y1-AI-5072

Mesh Terms

  • Adolescent
  • Adult
  • African Americans
  • DNA-Binding Proteins
  • Disease Progression
  • Genome-Wide Association Study
  • Genotype
  • HIV Infections
  • HIV-1
  • HLA-B Antigens
  • HLA-C Antigens
  • Humans
  • Male
  • Middle Aged
  • Phenotype
  • Polymorphism, Single Nucleotide
  • Viral Load
  • Young Adult