KLF1 regulates BCL11A expression and gamma- to beta-globin gene switching.
Journal:
Nat. Genet. 2010 SepAuthors:
Zhou D, Liu K, Sun CW, Pawlik KM, Townes TM
Abstract
We show that knockdown of KLF1 in human and mouse adult erythroid progenitors markedly reduces BCL11A levels and increases human gamma-globin/beta-globin expression ratios. These results suggest that KLF1 controls globin gene switching by directly activating beta-globin and indirectly repressing gamma-globin gene expression. Controlled knockdown of KLF1 in adult erythroid progenitors may provide a method to activate fetal hemoglobin expression in individuals with beta-thalassemia or sickle cell
...[more]disease.[less]
Mesh Headings:
Adult Stem Cells, Animals, Carrier Proteins, Cells, Cultured, Embryo, Mammalian, Erythropoiesis, Gene Expression Regulation, Developmental, Genes, Switch, Humans, Kruppel-Like Transcription Factors, Mice, Mice, Transgenic, Nuclear Proteins, beta-Globins, gamma-Globins