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The Lrs4-Csm1 monopolin complex associates with kinetochores during anaphase and is required for accurate chromosome segregation.

Lrs4 and Csm1, components of the monopolin complex, localize to the rDNA where they regulate rDNA maintenance and segregation. During meiosis, the complex also associates with kinetochores to bring about sister kinetochore co-orientation, an essential aspect of meiosis I chromosome segregation. We show here that the Lrs4-Csm1 complex associates with kinetochores during mitosis. This kinetochore localization is observed during anaphase and depends on the on the Mitotic Exit Network, a signaling cascade essential for the completion of mitosis. Furthermore, we find that Lrs4 and Csm1 are important for chromosome segregation fidelity. Our results reveal a previously unanticipated function for Lrs4-Csm1 in mitotic chromosome segregation.

Pubmed ID: 20818155

Authors

  • Brito IL
  • Monje-Casas F
  • Amon A

Journal

Cell cycle (Georgetown, Tex.)

Publication Data

September 1, 2010

Associated Grants

  • Agency: NIGMS NIH HHS, Id: GM62207
  • Agency: Howard Hughes Medical Institute, Id:

Mesh Terms

  • Anaphase
  • Cell Cycle Proteins
  • Chromosome Segregation
  • Kinetochores
  • Mitosis
  • Nuclear Proteins
  • Saccharomyces cerevisiae
  • Saccharomyces cerevisiae Proteins
  • Signal Transduction