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Fulminant hypertension in transgenic rats harbouring the mouse Ren-2 gene.

PRIMARY hypertension is a polygenic condition in which blood pressure is enigmatically elevated; it remains a leading cause of cardiovascular disease and death due to cerebral haemorrhage, cardiac failure and kidney disease. The genes for several of the proteins involved in blood pressure homeostasis have been cloned and characterized, including those of the renin-angiotensin system, which plays a central part in blood pressure control. Here we describe the introduction of the mouse Ren-2 renin gene into the genome of the rat and demonstrate that expression of this gene causes severe hypertension. These transgenic animals represent a model for hypertension in which the genetic basis for the disease is known. Further, as the transgenic animals do not overexpress active renin in the kidney and have low levels of active renin in their plasma, they also provide a new model for low-renin hypertension.

Pubmed ID: 2181319

Authors

  • Mullins JJ
  • Peters J
  • Ganten D

Journal

Nature

Publication Data

April 5, 1990

Associated Grants

None

Mesh Terms

  • Adrenal Glands
  • Angiotensin I
  • Angiotensin II
  • Animals
  • Animals, Genetically Modified
  • Disease Models, Animal
  • Enzyme Precursors
  • Gene Expression
  • Hypertension
  • Kidney
  • Mice
  • Mice, Inbred DBA
  • Rats
  • Renin
  • Submandibular Gland
  • Transfection