PDZ binding of TARPγ-8 controls synaptic transmission but not synaptic plasticity.
Journal:
Nat. Neurosci. 2011 NovAuthors:
Sumioka A, Brown TE, Kato AS, Bredt DS, Kauer JA, Tomita S
Abstract
The reduction in synaptic transmission and plasticity in mice lacking the hippocampus-enriched AMPA receptor (AMPAR) auxiliary subunit TARPγ-8 could be a result of a reduction in AMPAR expression or of the direct action of γ-8. We generated TARPγ-8Δ4 knock-in mice lacking the C-terminal PDZ ligand. We found that synaptic transmission and AMPARs were reduced in the mutant mice, but extrasynaptic AMPAR expression and long-term potentiation (LTP) were unaltered. Our findings suggest that there
...[more]are distinct TARP-dependent mechanisms for synaptic transmission and LTP.[less]
Mesh Headings:
Age Factors, Animals, Animals, Newborn, Biophysics, Calcium Channels, Electric Stimulation, Gene Expression Regulation, Developmental, Guanylate Kinase, Hippocampus, Long-Term Potentiation, Membrane Proteins, Mice, Mice, Transgenic, Models, Biological, Mutation, Neuronal Plasticity, PDZ Domains, Patch-Clamp Techniques, Synaptic Transmission, Synaptophysin, Synaptosomes