• Register
X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

X

Leaving Community

Are you sure you want to leave this community? Leaving the community will revoke any permissions you have been granted in this community.

No
Yes

Motor neuron position and topographic order imposed by β- and γ-catenin activities.

Neurons typically settle at positions that match the location of their synaptic targets, creating topographic maps. In the spinal cord, the organization of motor neurons into discrete clusters is linked to the location of their muscle targets, establishing a topographic map of punctate design. To define the significance of motor pool organization for neuromuscular map formation, we assessed the role of cadherin-catenin signaling in motor neuron positioning and limb muscle innervation. We find that joint inactivation of β- and γ-catenin scrambles motor neuron settling position in the spinal cord but fails to erode the predictive link between motor neuron transcriptional identity and muscle target. Inactivation of N-cadherin perturbs pool positioning in similar ways, albeit with reduced penetrance. These findings reveal that cadherin-catenin signaling directs motor pool patterning and imposes topographic order on an underlying identity-based neural map.

Pubmed ID: 22036570

Authors

  • Demireva EY
  • Shapiro LS
  • Jessell TM
  • Zampieri N

Journal

Cell

Publication Data

October 28, 2011

Associated Grants

  • Agency: NIGMS NIH HHS, Id: R01 GM062270
  • Agency: NIGMS NIH HHS, Id: R01 GM062270-09
  • Agency: NINDS NIH HHS, Id: R01 NS033245
  • Agency: NIGMS NIH HHS, Id: R01GM062270
  • Agency: NINDS NIH HHS, Id: R37 NS033245
  • Agency: NINDS NIH HHS, Id: R37 NS033245-19
  • Agency: Howard Hughes Medical Institute, Id:
  • Agency: Howard Hughes Medical Institute, Id:
  • Agency: Wellcome Trust, Id:

Mesh Terms

  • Animals
  • Biological Evolution
  • Body Patterning
  • Cadherins
  • Embryo, Mammalian
  • Mice
  • Motor Neurons
  • Mutation
  • Signal Transduction
  • Spinal Cord
  • Wnt Signaling Pathway
  • beta Catenin
  • gamma Catenin