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Functional inhibition of UQCRB suppresses angiogenesis in zebrafish.

As a subunit of mitochondrial complex III, UQCRB plays an important role in complex III stability, electron transport, and cellular oxygen sensing. Herein, we report UQCRB function regarding angiogenesis in vivo with the zebrafish (Danio rerio). UQCRB knockdown inhibited angiogenesis in zebrafish leading to the suppression of VEGF expression. Moreover, the UQCRB-targeting small molecule terpestacin also inhibited angiogenesis and VEGF levels in zebrafish, supporting the role of UQCRB in angiogenesis. Collectively, UQCRB loss of function by either genetic and pharmacological means inhibited angiogenesis, indicating that UQCRB plays a key role in this process and can be a prognostic marker of angiogenesis- and mitochondria-related diseases.

Pubmed ID: 23454382

Authors

  • Cho YS
  • Jung HJ
  • Seok SH
  • Payumo AY
  • Chen JK
  • Kwon HJ

Journal

Biochemical and biophysical research communications

Publication Data

April 19, 2013

Associated Grants

  • Agency: NICHD NIH HHS, Id: DP1 HD075622
  • Agency: NCCDPHP CDC HHS, Id: DP1HD075622

Mesh Terms

  • Amino Acid Sequence
  • Animals
  • Bicyclo Compounds
  • Carrier Proteins
  • Dose-Response Relationship, Drug
  • Embryo, Nonmammalian
  • Embryonic Development
  • Gene Expression Regulation, Developmental
  • Gene Knockdown Techniques
  • Mitochondria
  • Molecular Sequence Data
  • Morpholinos
  • Neovascularization, Physiologic
  • Prognosis
  • Vascular Endothelial Growth Factor A
  • Zebrafish