Integration of MAP kinase signal transduction pathways at the serum response element.
Journal:
Science 1995 JulAuthors:
Whitmarsh AJ, Shore P, Sharrocks AD, Davis RJ
Abstract
The ternary complex factor (TCF) subfamily of ETS-domain transcription factors bind with serum response factor (SRF) to the serum response element (SRE) and mediate increased gene expression. The TCF protein Elk-1 is phosphorylated by the JNK and ERK groups of mitogen-activated protein (MAP) kinases causing increased DNA binding, ternary complex formation, and transcriptional activation. Activated SRE-dependent gene expression is induced by JNK in cells treated with interleukin-1 and by ERK afte
...[more]r treatment with phorbol ester. The Elk-1 transcription factor therefore integrates MAP kinase signaling pathways in vivo to coordinate biological responses to different extracellular stimuli.[less]
Mesh Headings:
Animals, CHO Cells, Calcium-Calmodulin-Dependent Protein Kinases, Cricetinae, DNA-Binding Proteins, Gene Expression Regulation, Interleukin-1, JNK Mitogen-Activated Protein Kinases, MAP Kinase Kinase 1, Mitogen-Activated Protein Kinase 1, Mitogen-Activated Protein Kinase 3, Mitogen-Activated Protein Kinase Kinases, Mitogen-Activated Protein Kinases, Nuclear Proteins, Phosphorylation, Promoter Regions, Genetic, Protein-Serine-Threonine Kinases, Protein-Tyrosine Kinases, Proto-Oncogene Proteins, Serum Response Factor, Signal Transduction, Tetradecanoylphorbol Acetate, Transcription Factors, Transfection, ets-Domain Protein Elk-1, ets-Domain Protein Elk-4