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Requirement for Lim1 in head-organizer function.

Lim1 is a homeobox gene expressed in the organizer region of mouse embryos. To investigate the role of Lim1 during embryogenesis, a targeted deletion of the Lim1 gene was generated in embryonic stem cells. Embryos homozygous for the null allele lacked anterior head structures but the remaining body axis developed normally. A partial secondary axis developed anteriorly in some mutant embryos. Lim1 is thus an essential regulator of the vertebrate head organizer.

Pubmed ID: 7700351

Authors

  • Shawlot W
  • Behringer RR

Journal

Nature

Publication Data

March 30, 1995

Associated Grants

None

Mesh Terms

  • Animals
  • Base Sequence
  • Biological Markers
  • Brain
  • DNA Primers
  • Embryonic Induction
  • Embryonic and Fetal Development
  • Gene Deletion
  • Gene Expression
  • Gene Targeting
  • Genes, Homeobox
  • Head
  • Homeodomain Proteins
  • LIM-Homeodomain Proteins
  • Mesoderm
  • Mice
  • Mice, Inbred C57BL
  • Molecular Sequence Data
  • Phenotype
  • Stem Cells
  • Transcription Factors