Requirement for Lim1 in head-organizer function.

Journal:

Nature 1995 Mar

Authors:

Shawlot W, Behringer RR

Abstract

Lim1 is a homeobox gene expressed in the organizer region of mouse embryos. To investigate the role of Lim1 during embryogenesis, a targeted deletion of the Lim1 gene was generated in embryonic stem cells. Embryos homozygous for the null allele lacked anterior head structures but the remaining body axis developed normally. A partial secondary axis developed anteriorly in some mutant embryos. Lim1 is thus an essential regulator of the vertebrate head organizer.

PMID: 7700351

Mesh Headings:

Animals, Base Sequence, Biological Markers, Brain, DNA Primers, Embryonic Induction, Embryonic and Fetal Development, Gene Deletion, Gene Expression, Gene Targeting, Genes, Homeobox, Head, Homeodomain Proteins, LIM-Homeodomain Proteins, Mesoderm, Mice, Mice, Inbred C57BL, Molecular Sequence Data, Phenotype, Stem Cells, Transcription Factors