• Register
X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

X

Leaving Community

Are you sure you want to leave this community? Leaving the community will revoke any permissions you have been granted in this community.

No
Yes

Mouse model of X-linked chronic granulomatous disease, an inherited defect in phagocyte superoxide production.

Chronic granulomatous disease (CGD) is a recessive disorder characterized by a defective phagocyte respiratory burst oxidase, life-threatening pyogenic infections and inflammatory granulomas. Gene targeting was used to generate mice with a null allele of the gene involved in X-linked CGD, which encodes the 91 kD subunit of the oxidase cytochrome b. Affected hemizygous male mice lacked phagocyte superoxide production, manifested an increased susceptibility to infection with Staphylococcus aureus and Aspergillus fumigatus and had an altered inflammatory response in thioglycollate peritonitis. This animal model should aid in developing new treatments for CGD and in evaluating the role of phagocyte-derived oxidants in inflammation.

Pubmed ID: 7719350

Authors

  • Pollock JD
  • Williams DA
  • Gifford MA
  • Li LL
  • Du X
  • Fisherman J
  • Orkin SH
  • Doerschuk CM
  • Dinauer MC

Journal

Nature genetics

Publication Data

February 24, 1995

Associated Grants

None

Mesh Terms

  • Alleles
  • Animals
  • Aspergillosis
  • Aspergillus fumigatus
  • Cytochrome b Group
  • Disease Models, Animal
  • Female
  • Genetic Linkage
  • Granulomatous Disease, Chronic
  • Lung Diseases, Fungal
  • Macrophages
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Neutrophils
  • Peritonitis
  • Phagocytes
  • Staphylococcal Infections
  • Staphylococcus aureus
  • Stem Cells
  • Superoxides
  • X Chromosome