Functional role of type I and type II interferons in antiviral defense.
Journal:
Science 1994 JunAuthors:
Müller U, Steinhoff U, Reis LF, Hemmi S, Pavlovic J, Zinkernagel RM, Aguet M
Abstract
Mice lacking the known subunit of the type I interferon (IFN) receptor were completely unresponsive to type I IFNs, suggesting that this receptor chain is essential for type I IFN-mediated signal transduction. These mice showed no overt anomalies but were unable to cope with viral infections, despite otherwise normal immune responses. Comparison of mice lacking either type I or type II IFN receptors showed that, at least in response to some viruses, both IFN systems are essential for antiviral d
...[more]efense and are functionally nonredundant.[less]
Mesh Headings:
Alphavirus Infections, Animals, Antibodies, Viral, Disease Susceptibility, Immunity, Innate, Interferon Type I, Interferon-gamma, Lymphocytic Choriomeningitis, Membrane Proteins, Mice, Mutation, Receptor, Interferon alpha-beta, Receptors, Interferon, Rhabdoviridae Infections, Semliki forest virus, Signal Transduction, T-Lymphocytes, Vesicular stomatitis Indiana virus, Virus Diseases