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Deletion of a DNA polymerase beta gene segment in T cells using cell type-specific gene targeting.

Authors:
Gu H, Marth JD, Orban PC, Mossmann H, Rajewsky K
Affiliation:
Journal:
Science (New York, N.Y.)

Abstract

Deletion of the promoter and the first exon of the DNA polymerase beta gene (pol beta) in the mouse germ line results in a lethal phenotype. With the use of the bacteriophage-derived, site-specific recombinase Cre in a transgenic approach, the same mutation can be selectively introduced into a particular cellular compartment-in this case, T cells. The impact of the mutation on those cells can then be analyzed because the mutant animals are viable.

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