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Protein folding in the central cavity of the GroEL-GroES chaperonin complex.

Authors:
Mayhew M, da Silva AC, Martin J, Erdjument-Bromage H, Tempst P, Hartl FU
Affiliation:
Journal:
Nature

Abstract

The chaperonin GroEL is able to mediate protein folding in its central cavity. GroEL-bound dihydrofolate reductase assumes its native conformation when the GroES cofactor caps one end of the GroEL cylinder, thereby discharging the unfolded polypeptide into an enclosed cage. Folded dihydrofolate reductase emerges upon ATP-dependent GroES release. Other proteins, such as rhodanese, may leave GroEL after having attained a conformation that is committed to fold. Incompletely folded polypeptide rebinds to GroEL, resulting in structural rearrangement for another folding trial in the chaperonin cavity.

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