Requirement for the transcription factor LSIRF/IRF4 for mature B and T lymphocyte function.
Journal:
Science 1997 JanAuthors:
Mittrücker HW, Matsuyama T, Grossman A, Kündig TM, Potter J, Shahinian A, Wakeham A, Patterson B, Ohashi PS, Mak TW
Abstract
Lymphocyte-specific interferon regulatory factor (LSIRF) (now called IRF4) is a transcription factor expressed only in lymphocytes. Mice deficient in IRF4 showed normal distribution of B and T lymphocyes at 4 to 5 weeks of age but developed progressive generalized lymphadenopathy. IRF4-deficient mice exhibited a profound reduction in serum immunoglobulin concentrations and did not mount detectable antibody responses. T lymphocyte function was also impaired in vivo; these mice could not generate
...[more]cytotoxic or antitumor responses. Thus, IRF4 is essential for the function and homeostasis of both mature B and mature T lymphocytes.[less]
Mesh Headings:
Animals, Antigen Presentation, B-Lymphocytes, Bone Marrow Cells, Cytotoxicity, Immunologic, DNA-Binding Proteins, Female, Gene Targeting, Graft vs Host Reaction, Immunization, Immunoglobulins, Interferon Regulatory Factors, Lymphatic Diseases, Lymphocyte Activation, Lymphocyte Subsets, Lymphoid Tissue, Male, Mast-Cell Sarcoma, Mice, Mice, Inbred C57BL, Mice, SCID, Neoplasm Transplantation, T-Lymphocytes, T-Lymphocytes, Cytotoxic, Transcription Factors