Phenotype of mice lacking functional Deleted in colorectal cancer (Dcc) gene.
Journal:
Nature 1997 AprAuthors:
Fazeli A, Dickinson SL, Hermiston ML, Tighe RV, Steen RG, Small CG, Stoeckli ET, Keino-Masu K, Masu M, Rayburn H, Simons J, Bronson RT, Gordon JI, Tessier-Lavigne M, Weinberg RA
Abstract
The DCC (Deleted in colorectal cancer) gene was first identified as a candidate for a tumour-suppressor gene on human chromosome 18q. More recently, in vitro studies in rodents have provided evidence that DCC might function as a receptor for the axonal chemoattractant netrin-1. Inactivation of the murine Dcc gene caused defects in axonal projections that are similar to those observed in netrin-1-deficient mice but did not affect growth, differentiation, morphogenesis or tumorigenesis in mouse in
...[more]testine. These observations fail to support a tumour-suppressor function for Dcc, but are consistent with the hypothesis that DCC is a component of a receptor for netrin-1.[less]
Mesh Headings:
Animals, Axons, Brain, Brain Neoplasms, Cell Adhesion Molecules, Cell Division, Chimera, Chromosome Mapping, Colorectal Neoplasms, Gene Targeting, Genes, DCC, Humans, Intestinal Mucosa, Intestinal Neoplasms, Intestinal Polyps, Mice, Mice, Inbred C57BL, Mutagenesis, Nerve Growth Factors, Phenotype, Receptors, Cell Surface, Spinal Cord, Tumor Suppressor Proteins