A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis.
Journal:
Cell 1998 MarAuthors:
Puigserver P, Wu Z, Park CW, Graves R, Wright M, Spiegelman BM
Abstract
Adaptive thermogenesis is an important component of energy homeostasis and a metabolic defense against obesity. We have cloned a novel transcriptional coactivator of nuclear receptors, termed PGC-1, from a brown fat cDNA library. PGC-1 mRNA expression is dramatically elevated upon cold exposure of mice in both brown fat and skeletal muscle, key thermogenic tissues. PGC-1 greatly increases the transcriptional activity of PPARgamma and the thyroid hormone receptor on the uncoupling protein (UCP-1)
...[more] promoter. Ectopic expression of PGC-1 in white adipose cells activates expression of UCP-1 and key mitochondrial enzymes of the respiratory chain, and increases the cellular content of mitochondrial DNA. These results indicate that PGC-1 plays a key role in linking nuclear receptors to the transcriptional program of adaptive thermogenesis.[less]
Mesh Headings:
Adaptation, Physiological, Adipose Tissue, Brown, Adrenergic beta-Agonists, Amino Acid Sequence, Animals, Body Temperature Regulation, Cloning, Molecular, Cold Temperature, Energy Metabolism, Gene Expression Regulation, Male, Mice, Mice, Inbred C57BL, Molecular Sequence Data, RNA, Messenger, Receptors, Cytoplasmic and Nuclear, Transcription Factors, Transcription, Genetic