• Register
X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

X

Leaving Community

Are you sure you want to leave this community? Leaving the community will revoke any permissions you have been granted in this community.

No
Yes

Serotonin receptor 1A knockout: an animal model of anxiety-related disorder.

To investigate the contribution of individual serotonin (5-hydroxytryptamine; 5-HT) receptors to mood control, we have used homologous recombination to generate mice lacking specific serotonergic receptor subtypes. In the present report, we demonstrate that mice without 5-HT1A receptors display decreased exploratory activity and increased fear of aversive environments (open or elevated spaces). 5-HT1A knockout mice also exhibited a decreased immobility in the forced swim test, an effect commonly associated with antidepressant treatment. Although 5-HT1A receptors are involved in controlling the activity of serotonergic neurons, 5-HT1A knockout mice had normal levels of 5-HT and 5-hydroxyindoleacetic acid, possibly because of an up-regulation of 5-HT1B autoreceptors. Heterozygote 5-HT1A mutants expressed approximately one-half of wild-type receptor density and displayed intermediate phenotypes in most behavioral tests. These results demonstrate that 5-HT1A receptors are involved in the modulation of exploratory and fear-related behaviors and suggest that reductions in 5-HT1A receptor density due to genetic defects or environmental stressors might result in heightened anxiety.

Pubmed ID: 9826725

Authors

  • Ramboz S
  • Oosting R
  • Amara DA
  • Kung HF
  • Blier P
  • Mendelsohn M
  • Mann JJ
  • Brunner D
  • Hen R

Journal

Proceedings of the National Academy of Sciences of the United States of America

Publication Data

November 24, 1998

Associated Grants

None

Mesh Terms

  • Animals
  • Anxiety Disorders
  • Autoradiography
  • Brain
  • Disease Models, Animal
  • Female
  • Humans
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Inbred Strains
  • Mice, Knockout
  • Motor Activity
  • Neurons
  • Receptors, Serotonin
  • Receptors, Serotonin, 5-HT1
  • Recombination, Genetic
  • Serotonin
  • Tritium