OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis.
Journal:
Nature 1999 JanAuthors:
Kong YY, Yoshida H, Sarosi I, Tan HL, Timms E, Capparelli C, Morony S, Oliveira-dos-Santos AJ, Van G, Itie A, Khoo W, Wakeham A, Dunstan CR, Lacey DL, Mak TW, Boyle WJ, Penninger JM
Abstract
The tumour-necrosis-factor-family molecule osteoprotegerin ligand (OPGL; also known as TRANCE, RANKL and ODF) has been identified as a potential osteoclast differentiation factor and regulator of interactions between T cells and dendritic cells in vitro. Mice with a disrupted opgl gene show severe osteopetrosis and a defect in tooth eruption, and completely lack osteoclasts as a result of an inability of osteoblasts to support osteoclastogenesis. Although dendritic cells appear normal, opgl-defi
...[more]cient mice exhibit defects in early differentiation of T and B lymphocytes. Surprisingly, opgl-deficient mice lack all lymph nodes but have normal splenic structure and Peyer's patches. Thus OPGL is a new regulator of lymph-node organogenesis and lymphocyte development and is an essential osteoclast differentiation factor in vivo.[less]
Mesh Headings:
Animals, B-Lymphocytes, Bone Remodeling, Carrier Proteins, Cell Differentiation, Cells, Cultured, Cytokines, Dendritic Cells, Embryonic and Fetal Development, Female, Gene Targeting, Growth Substances, Hematopoiesis, Extramedullary, Hematopoietic Stem Cells, Leukopoiesis, Lymph Nodes, Lymphocyte Activation, Lymphocytes, Male, Membrane Glycoproteins, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Molecular Sequence Data, Mutagenesis, Osteoclasts, Osteogenesis, Osteopetrosis, RANK Ligand, Receptor Activator of Nuclear Factor-kappa B, T-Lymphocytes, Thymus Gland