The goals of Antibiotic Resistance Genes Database (ARGB) are to provide a centralized compendium of information on antibiotic resistance, to facilitate the consistent annotation of resistance information in newly sequenced organisms, and also to facilitate the identification and characterization of new genes.
ARGB contains six types of database groups:
- Resistance Type: This database contains information, such as resistance profile, mechanism, requirement, epidemiology for each type.
- Resistance Gene: This database contains information, such as resistance profile, resistance type, requirement, protein and DNA sequence for each gene.This database only includes NON-REDUNDANT, NON-VECTOR, COMPLETE genes.
- Antibiotic: This database contains information, such as producer, action mechanism, resistance type, for each gene.
- Resistance Gene(NonRD): This database contains the same information as Resistance Gene. It does NOT include NON-REDUNDANT, NON-VECTOR genes, but includes INCOMPLETE genes.
- Resistance Gene(ALL): This database contains the same information as Resistance Gene. It includes all REDUNDANT, VECTOR AND INCOMPLETE genes.
- Resistance Species: This database contains resistance profile and corresponding resistance genes for each species.
Furthermore, ARDB also contians three types BLAST database:
- Resistance Genes Complete: Contains only NON-REDUNDANT, NON-VECTOR, COMPLETE genes sequences.
- Resistance Genes Non-redundant: Contains NON-REDUNDANT, NON-VECTOR, COMPLETE, INCOMPLETE genes sequences.
- Resistance Genes All: Contains all REDUNDANT, VECTOR, COMPLETE, INCOMPLETE genes sequences.
Lastly, ARDB provides four types of Analytical tools:
- Normal BLAST: This function allows an user to input a DNA or protein sequence, and find similar DNA (Nucleotide BLAST) or protein (Protein BLAST) sequences using blastn, blastp, blastx, tblastn, tblastx
- RPS BLAST: A web RPSBLAST (RPS BLAST) interface is provided to align a query sequence against the Position Specific Scoring Matrix (PSSM) for each type. Normally, this will give the same annotation information as using regular BLAST mentioned above.
- Multiple Sequences BLAST (Genome Annotation): This function allows an user to annotate multiple (less than 5000) query sequences in FASTA format.
- Mutation Resistance Identification: This function allows an user to identify mutations that will cause potential antibiotic resistance, for 12 genes (16S rRNA, 23S rRNA, gyrA, gyrB, parC, parE, rpoB, katG, pncA, embB, folP, dfr). ������
:Sponsors: ARDB is funded by Uniformed Services University of the Health Sciences, administered by the Henry Jackson Foundation.
Resource Type: Resource
Version: Latest Version
genome, antibiotic, antibiotic resistance gene, dna, metagenome, mutation resistance, prokaryotic genomic database, protein
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Additional Resource Types
data computation service, database
Resource PubMed IDs
PMID: 20047673, PMID: 21595903, PMID: 22140215, PMID: 22782487, PMID: 23056610, PMID: 24225317, PMID: 24334622
Created 4 years ago by Anonymous