X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Human Potential Tumor Associated Antigen database

To accelerate the process of tumor antigen discovery, we generated a publicly available Human Potential Tumor Associated Antigen database (HPtaa) with pTAAs identified by insilico computing. 3518 potential targets have been included in the database, which is freely available to academic users. It successfully screened out 41 of 82 known Cancer-Testis antigens, 6 of 18 differentiation antigen, 2 of 2 oncofetal antigen, and 7 of 12 FDA approved cancer markers that have Gene ID, therefore will provide a good platform for identification of cancer target genes. This database utilizes expression data from various expression platforms, including carefully chosen publicly available microarray expression data, GEO SAGE data, Unigene expression data. In addition, other relevant databases required for TAA discovery such as CGAP, CCDS, gene ontology database etc, were also incorporated. In order to integrate different expression platforms together, various strategies and algorithms have been developed. Known tumor antigens are gathered from literature and serve as training sets. A total tumor specificity penalty was computed from positive clue penalty for differential expression in human cancers, the corresponding differential ratio, and normal tissue restriction penalty for each gene. We hope this database will help with the process of cancer immunome identification, thus help with improving the diagnosis and treatment of human carcinomas.

URL: http://www.bioinfo.org.cn/hptaa/

Resource ID: nif-0000-02987     Resource Type: Resource     Version: Latest Version

Keywords

cancer, tumor, tumor-associated antigen

Old URLs

http://www.hptaa.org

Resource PubMed IDs

PMID: 25369839

Synonyms

HPtaa Database

Curation Status

curated

Parent Organization

Additional Resource Types

database

Supercategory

Resource

Resource Status

Last checked up;

Original Submitter

Anonymous

Version Status

Curated

Submitted On

12:00am September 21, 2010

Originated From

SciCrunch

Changes from Previous Version

First Version

Version 1

Created 4 years ago by Anonymous