Blinding - What is this?

  • Blinding of investigator or analysis

    • Applicable guidelines: MDAR, NIH, CONSORT, ARRIVE

    • A statement discussing the degree to which experimenters were unaware (or blinded) of group assignment and/or outcome assessment.

    • Blinding in preclinical studies short video (Anita Bandrowski); short video of blinding types in clinical trials (Terry Shaneyfelt); tips for surgical trials Karanicolas et al (2010)

    • Additional explanation for animal experiments from ARRIVE guidelines

  • What does SciScore do about blinding?

    • If we find a blinding statement, then SciScore expects to find the following items (randomization, power);

  • Example sentences

    • Responses were then scored by an experimenter blinded to injection condition and experimental cohort.

    • …sensitivity to different filament force stimuli was measured by two blinded
      investigators.

    • All analyses were performed blinded such that experimenters performing surgery, behavioral testing, anatomical measures, and data analysis were unaware of the genotypes and treatments.

    • …a veterinarian made the ultrasound examination of the right and left testes and calculated the testicular volume of all rats, blindly, without prior knowledge of the animal groups evaluated.