Cell line RRID? What is this?

All cell lines should be listed with the company or source where they were obtained, the catalog number (if applicable), and the RRID from Cellosaurus. Cellosaurus contains the ICLAC.org list of problematic cell lines, thus looking at the cell line record ensures that authors are made aware of any warnings on cell lines or other known issues.

Please make sure that all of the cells used in your study are authenticated using STR profiling and checking for contamination. Not discussing how cells were authenticated will reduce your score.

RRIDs are unique identifiers for cell lines and other resources that largely overlap with the resource types that have been labeled as particularly problematic by the National Institutes of Health in recent changes to their grant review criteria, please see "key biological resources", e.g., antibodies, cell lines and transgenic organisms. The RRID initiative is led by community repositories that provide persistent, unique identifiers to their resources, such as transgenic mice, salamanders, antibodies, cell lines, plasmids and software projects such as statistical software. RRIDs are described on the rrids.org website and in a primer by Bandrowski and Martone in 2016.

RRIDs are unique numbers that resolve to a particular database record, for example, the RRID:CVCL_0030 resolves to this record for the HeLa cell line: https://www.cellosaurus.org/CVCL_0030

Potential problems with SciScore recognition

My cell lines have red text next to them stating they are problematic. I know this information and it does not impact my study. Am I getting “full credit” for this?

The red text is only informational and does not impact the score.

SciScore recognized a cell line but I did not use one, it is a different reagent.

Sometimes clarifying the type of reagent that is being used can help, but not in all cases. Please contact us if you are having problems with this. In most cases this will not substantially impact your score negatively.

My cell lines are all recognized and suggested accurately, why don’t I get “full credit”?

Please add the RRID for each resource into your paper, not just the catalog number. Please make sure that the antibody record is accurate and matches your antibody records.

RRID portal link https://rrid.site -> cell lines -> search

SciScore misses a lot of cell lines in the sentence that it recognizes. What should I do?

Please add the RRID for each cell line into your paper, not just the catalog number. SciScore sometimes gets confused about which information is associated with which cell line and that may duplicate a record. The best way to get SciScore and your readers to be less confused is to add each cell line with all of its information together. Sentences that discuss cells from one company then those from another company tend to be more problematic.

Including a STAR reagent table in your manuscript is a good way to clearly identify all reagents used in your study. SciScore reads STAR tables so don’t forget to submit the table with your methods section.